MGF (Mechano growth
also known as IGF-1 Ec
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|One Letter Sequence||YQPPSTNKNTKSQRRKGSTFEEHK-NH2|
|Physical Apperance||White Powder|
|Form & Formulations||Sterile Filtered white lyophilized (freeze-dried)|
|Stability||2 months at room temperature 24 months from date of receipt, 20 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, 20 to 70 °C under sterile conditions after reconstitution.|
|Purity||>98% by RP-HPLC|
|Storage||Lyophilized MGF although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution FST should be stored at 4°C between 2-7 days and for future use below -18°C.|
Mechano Growth Factor (MGF) is a spliced variant of the IGF gene, which increases stem cell count in the muscle and allows for muscle fibers to fuse and mature. This is a process required for growth of adult muscle. It is derived from IGF-1 but its sequence differs from the systemic IGF-1 produced by the liver. Natural MGF is produced locally and does not travel into the blood stream. Synthetic MGF on the other hand is water based and when administered intramuscularly it will travel into the blood stream.
MGF is expressed by mechanically overloaded muscle and plays a role in tissue repair and adaptation. It is expressed as a pulse following muscle damage and is involved in the activation of muscle satellite cells. The cells donate nuclei to the muscle fibers that are required for repair and for the hypertrophy processes, which may have similar regulatory mechanisms. It is related very closely to insulin like growth factor, but is different in several key ways which make it a potentially even more powerful substance for the creation of lean muscle mass. When muscles are stressed to the breakdown point their recovery when boosted with Mechano Growth Factor will be greater, and more muscle size and mass is likely to be gained. The primary and most effective means of reducing overall body fat percentage is to increase the lean muscle mass. Increased lean muscle will result in the usage of fat stores and calories much more effectively, creating an overall leaner body and physique.
MGF is also known as IGF-1Ec. This C-terminal peptide was found to function independently from the rest of the molecule. IGF-1 exists in multiple isoforms (tissue specific proteins of functional and structural similarity). One isoform, which differs from the systemic or liver type, happens to be particularly sensitive to mechanical signals that are a direct result of exercise overload. Immediately following the mechanical use of a muscle, the IGF-I gene is spliced towards MGF, which initiates hypertrophy and repair of local muscle damage. One of the principle problems that have been associated with aging is the loss of muscle mass. This loss of muscle mass has been directly linked to Hormone deficiencies. As people age, they frequently are no longer producing Hormones in the required amounts. This is because their bodies lose the ability to naturally produce the Mechano Growth Factor, which helps to repair damaged muscle tissue and to build more lean muscle mass. This is linked to the decline in GH that serves as the primary instigator in the production of MGF
Recent studies have also discovered two clones of the hybridonoma secreting monoclonal antibodies to the mechano-growth factor have been developed by cell fusion technique. The monoclonal antibody of one clone recognizes the human MGF peptide that is absent in insulin-like growth factor-1 (IGF-1) which comprised mostly of amino acids from 87-111. Enzyme-linked immunosorbent assay (ELISA) has further shown that there is a high affinity binding constants with the full length of the MGF and the 87-111 fragments of the clones. These can then be used for the quantitation of the MGF through sandwich type assay (Kravchenko et al. 2006).
For Research Purpose only, Not for Human Consumption